Peptide therapy Brain, mood and sleep

DSIP Delta sleep-inducing peptide

What it is and what people take it for, in plain language.

Updated October 2026Further reading

What is DSIP?

A peptide first isolated in 1977 from the blood of rabbits, studied as a possible sleep signal.

What do people take DSIP for?

Deeper sleep, stress.

Should I talk to a physician about DSIP?

If you are considering it, or already using it, a physician can look at your history, your labs and your goals, and at what else might explain what you are hoping to change. At Aether Medicine in King of Prussia, near Philadelphia, or by video for patients in Pennsylvania.

Or call 484-806-1101

Further reading

  1. Schoenenberger GA, Monnier M. Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Proc Natl Acad Sci U S A. 1977. pubmed.ncbi.nlm.nih.gov/265572/
  2. Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006. pubmed.ncbi.nlm.nih.gov/16539679/
  3. Bes F, et al. Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study. Neuropsychobiology. 1992. pubmed.ncbi.nlm.nih.gov/1299794/

Educational information only, not medical advice. Reading this page does not create a physician-patient relationship.

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