Peptide therapy Weight and metabolism
MOTS-c
What it is, what people take it for, and how it works, in plain language.
What is MOTS-c?
A peptide encoded in the mitochondrial genome, first described in 2015.
What do people take MOTS-c for?
Metabolism and exercise performance.
How does MOTS-c work?
It is made from instructions in mitochondrial DNA, and is studied for its role in how muscle uses energy.
Should I talk to a physician about MOTS-c?
If you are considering it, or already using it, a physician can look at your history, your labs and your goals, and at what else might explain what you are hoping to change. At Aether Medicine in King of Prussia, near Philadelphia, or by video for patients in Pennsylvania.
Further reading
- Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015. doi.org/10.1016/j.cmet.2015.02.009
- Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021. doi.org/10.1038/s41467-020-20790-0
- ClinicalTrials.gov, NCT07505745. clinicaltrials.gov/study/NCT07505745
Educational information only, not medical advice. Reading this page does not create a physician-patient relationship.