Peptide therapy Healing and recovery

TB-500 Thymosin beta-4 fragment

What it is, what people take it for, and how it works, in plain language.

Updated October 2026Further reading

What is TB-500?

A synthetic peptide based on a short region of thymosin beta-4, a naturally occurring protein involved in cell migration and repair.

What do people take TB-500 for?

Injury healing and recovery.

How does TB-500 work?

It is modeled on the part of thymosin beta-4 that binds actin, a protein cells use to move and repair.

Questions people ask about TB-500

Is TB-500 the same as thymosin beta-4?

No. TB-500 is a short synthetic peptide based on one region of thymosin beta-4, which is a full natural protein.

Should I talk to a physician about TB-500?

If you are considering it, or already using it, a physician can look at your history, your labs and your goals, and at what else might explain what you are hoping to change. At Aether Medicine in King of Prussia, near Philadelphia, or by video for patients in Pennsylvania.

Or call 484-806-1101

Further reading

  1. Esposito S, et al. Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential. Drug Test Anal. 2012. doi.org/10.1002/dta.1402
  2. Ho EN, et al. Doping control analysis of TB-500, a synthetic version of an active region of thymosin β4, in equine urine and plasma. J Chromatogr A. 2012. doi.org/10.1016/j.chroma.2012.09.043
  3. Sosne G, et al. Thymosin β4 significantly improves signs and symptoms of severe dry eye in a phase 2 randomized trial. Cornea. 2015. doi.org/10.1097/ICO.0000000000000379

Educational information only, not medical advice. Reading this page does not create a physician-patient relationship.

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